. Author manuscript; available in PMC: 2020 Mar 8.

Published in final edited form as: J Bone Miner Res. 2018 Jun 19;33(7):1199–1208. doi: 10.1002/jbmr.3471

Table 4.

Summary of Studies Regarding Serum C-terminal Telopeptide of Type I Collagen in Relation to Hip Fracture Risk (Hazard Ratio [HR] or Odds Ratio [OR] (95% Confidence Interval [CI]))

Study authors (reference)	Unadjusted HR or OR (95% CI)	Adjusted HR or OR (95% CI if available)-covariates
Chapurlat et al ⁽¹⁹⁾	HR 1.9 (1.05–3.4) for serum CTX in highest quartile	HR 1.75-adjusted for body weight, HR 1.48-adjusted for gait speed HR 1.57-adjusted for femoral neck BMD
Dai et al ⁽²⁷⁾	OR 1.43 (1.06–1.94) Per SD increase in CTX	OR 1.78 (1.24–2.56) per SD increase in CTX-adjusted for age, sex, body mass index, education level, smoking status, physical activity level, diabetes mellitus-men and women were analyzed together because some associations were not statistically significant in gender-stratified analyses.
Dobnig et al ⁽²³⁾	Not described	HR 1.27 (0.45–3.60) per increment of 1 ng/ml-adjusted for age, body mass index, mobility score, past fractures, creatinine clearance rate, and calcaneal stiffness
Gerdhem et al ⁽²¹⁾	OR 1.01 (0.48–2.11) for serum CTX in highest quartile	OR 1.53 (0.79–2.97)-adjusted for femoral neck BMD
Ivaska et al ⁽²²⁾	Not described	Not described