Table 1. Genes with a peritoneum fitness defect.
Upper panel: the top 15 (out of 22 genes) peritoneum fitness conferring genes with a peritoneum Z-score ≥2 after removing the genes with an HFF fitness score ≤−1.25 (Sidik et al., 2016). Lower panel: organ fitness conferring genes with a lung Z-score ≥2 or a fitness score of ≤−1 in heart, brain and eyes. The 22 peritoneum fitness conferring genes were excluded. The genes are ranked according to the lung Z-score. The peritoneum and lung fitness scores are averages (n=10). Heart, brain, and eye fitness scores were calculated from the pooled sequence data of 9, 7 and 9 mice, respectively. See Table S4 for the complete list.
| Gene ID | Peritoneum fitness score | Peritoneum Z-score | Lung fitness score | Lung Z-score | Heart fitness score | Brain fitness score | Eye fitness score | Product description |
|---|---|---|---|---|---|---|---|---|
| Genes with a peritoneum fitness defect | ||||||||
| TGGT1_203030 | −1.2 | 20.5 | −1.6 | 17.1 | −0.5 | −1.8 | −5.6 | N-methyl-D-aspartate receptor |
| TGGT1_266366 | −2.1 | 18.0 | −2.0 | 15.7 | −1.6 | −1.8 | −8.2 | BT1 family protein |
| TGGT1_205350 | −0.9 | 3.3 | −1.2 | 11.3 | −1.8 | −2.3 | −1.7 | GNS1/SUR4 family protein, |
| TGGT1_269950 | −0.4 | 3.3 | −0.8 | 6.6 | −1.7 | −1.4 | −8.0 | Hypothetical protein |
| TGGT1_215220 | −0.5 | 3.0 | −0.6 | 5.1 | −1.3 | −1.2 | −1.7 | GRA22 |
| TGGT1_200590 | −0.2 | 2.5 | −0.4 | 3.3 | −1.1 | −0.2 | −0.8 | Toxoplasma gondii family C protein |
| TGGT1_321170 | −0.2 | 3.9 | −0.2 | 3.0 | −1.1 | −1.1 | −0.9 | Toxoplasma gondii family C protein |
| TGGT1_259940 | −0.5 | 3.3 | −0.5 | 2.6 | −1.5 | −1.5 | −0.6 | Hypothetical protein |
| TGGT1_307260 | −0.5 | 4.6 | −0.6 | 2.5 | −0.8 | −0.3 | −4.5 | Toxoplasma gondii family C protein |
| TGGT1_273905 | −0.3 | 2.4 | −0.2 | 2.4 | −0.8 | −1.3 | −3.1 | Hypothetical protein |
| TGGT1_228770 | −0.2 | 2.4 | −0.2 | 2.3 | −0.6 | −1.3 | −6.3 | Hypothetical protein |
| TGGT1_269420 | −0.3 | 3.8 | −0.1 | 1.4 | −1.4 | −0.9 | −3.0 | Hypothetical protein |
| TGGT1_297100 | −0.2 | 2.3 | −0.5 | 0.9 | −0.7 | −1.9 | −5.2 | Hypothetical protein |
| TGGT1_231625 | −0.1 | 2.1 | −0.1 | 0.9 | −1.0 | −1.1 | −2.7 | Hypothetical protein |
| TGGT1_255650 | −0.3 | 3.2 | −0.1 | 0.9 | −1.3 | −1.9 | −3.4 | TgDHHC8 |
| Genes with an organ fitness defect | ||||||||
| TGGT1_288650 | −0.1 | 0.1 | −0.9 | 7.9 | −1.1 | −1.0 | −5.4 | GRA12 |
| TGGT1_290700 | −0.1 | 0.6 | −0.5 | 6.4 | −1.0 | −0.5 | −1.9 | GRA25 |
| TGGT1_280380 | 0.3 | −1.6 | −0.3 | 4.0 | −1.3 | −0.3 | −1.4 | Poly (ADP-ribose) glycohydrolase |
| TGGT1_247520 | 0.1 | −0.2 | −0.3 | 3.1 | −0.9 | −1.1 | −1.9 | Hypothetical protein-TgWIP |
| TGGT1_254470 | −0.1 | 1.3 | −0.3 | 3.0 | −1.1 | −1.3 | −1.7 | MYR1 |
| TGGT1_224090 | −0.3 | 1.4 | −0.3 | 2.8 | −1.0 | −0.6 | −3.6 | Enoyl-CoA hydratase/isomerase |
| TGGT1_270240 | 0.1 | 0.4 | −0.2 | 2.4 | −0.8 | −1.2 | −2.9 | MAG1 |
| TGGT1_312420 | −0.2 | 1.2 | −0.3 | 1.3 | −1.2 | −2.1 | −2.0 | GRA38 |
| TGGT1_261400 | 0.0 | 0.3 | −0.4 | 0.9 | −1.8 | −2.4 | −2.1 | Hypothetical protein-PfVFT1 orthologue |