Table 1.

Performance of biological tests for the diagnosis of advanced fibrosis and cirrhosis in patients with biopsy‐proven ALD

Tests	Patients, n	Endpoint	AUC	Se, %	Sp, %	NPV, %	PPV, %
ELF ≥10.532	289	F3‐F4	0.92‐0.94	79	91	94	71
FT ≥0.5832	289	F3‐F4	0.88‐0.88	67	87	90	60
Fibrometer33, 34	218	F3‐F4	0.83‐0.94	91.8‐91.8	92.3‐92.3	NA	NA
Hepascore33, 34	218	F3‐F4	0.83‐0.92	NA	NA	NA	NA
APRI ≥1.032	289	F3‐F4	0.80‐0.85	38	90	83	52
Fib‐4 ≥ 3.2532	289	F3‐F4	0.85‐0.89	58	91	88	64

Abbreviations: ALD, alcohol‐related liver disease; APRI, aspartate transaminase‐platelet ratio index; AUC, area under the curve; ELF, Enhanced Liver Fibrosis; FT, Fibrotest; Se, sensitivity; Sp, specificity; NPV, negative predictive value; PPV, positive predictive value; NA, not available.