Fig. 1.

RNA-seq of PO-induced CH and mHF in human and mouse myocardium. a EF of AS patients with CH and mHF. Error bars represent mean ± SEM. b Workflow of RNA-seq screen of human NF samples (n = 4), human AS patients with CH (n = 5) and mHF (n = 5) and c of mice 1 week (CH) (n = 4) and 8 weeks (mHF) after TAC (n = 5). Error bars represent mean ± SD. d EF of mice 1wTAC and 8wTAC. Error bars represent mean ± SEM. e Expression profiles of conserved DEGs in human and mouse transcriptomes during disease progression illustrated as heatmap. The light blue to dark red shading scale reflects the logFC of median normalized counts. Genes expressed in the same way in human and mouse datasets according to disease progression are framed. CRISPLD1 is highlighted in red. EF ejection fraction, AS aortic stenosis, CH compensated hypertrophy, mHF moderate heart failure, NF non-failing control, 1wTAC 1 week post-transverse aortic constriction, 8wTAC 8 weeks post-transverse aortic constriction, DEGs differentially expressed genes, logFC log fold change. n = 4–5/group