. 2020 Mar 5;8:e8730. doi: 10.7717/peerj.8730

Table 5. The expression of the top 5 hub genes identified from the PPI network in microarray training datasets and the OE RNA-sequencing validation dataset GSE105764.

Gene symbol	Gene description	OE RNA-sequencing dataset GSE105764		The merged OE dataset of GSE7305 and GSE7307		The individual PE dataset E-MTAB-694		The individual DIE dataset GSE25628
		Log2FC	P-Value	Log2FC	P-Value	Log2FC	P-Value	Log2FC	P-Value
RRM2	Ribonucleotide Reductase Regulatory Subunit M2	−2.545059091	5.65568E-06	−2.902398466	6.14787E-10	−3.521816066	1.01611E-08	−1.908309782	0.01636418
AURKB	Aurora Kinase B	−2.311429822	3.34652E-05	−1.42932862	3.39568E-09	−1.911232107	3.34734E-06	−1.0990377	0.039806461
CCNB1	Cyclin B1	−1.856061436	5.54985E-05	−2.207580173	3.967E-09	−2.161536326	3.96789E-06	−1.264483101	0.047858003
CCNB2	Cyclin B2	−1.825733268	0.000537883	−1.938433806	3.70498E-09	−2.689873382	7.46834E-07	−1.446885624	0.044121405
DTL	Denticleless E3 Ubiquitin Protein Ligase Homolog	−1.228039999	0.003406252	−1.757599775	1.88499E-08	−1.998898813	5.57114E-07	−1.372163345	0.032638654

Notes.