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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Curr Genet. 2019 Sep 9;66(2):303–311. doi: 10.1007/s00294-019-01033-2

Figure 2. Hyperactive Dynein disrupts HDR.

Figure 2

A)Schematic depicting normal DNA damage signaling, leading to inhibition of dynein in the cytoplasm and halting nuclear movement.

B) Schematic depicting hyperactive dynein pulling the nucleus far into the bud during DNA damage, and thereby disrupting HDR.