Table 2.
Effect of phytoextracts on cancer cell line, HeLa.
Drug/phytoextracts | Concentration | Percentage cell viability | ||
Control/untreated cell lines | — | 100 ± 0.005 | ||
Curcumin | 15 μM | 49.85±0.05∗∗∗∗ | ||
| ||||
Methanol extract | Distilled water extract | Chloroform extract | ||
Whole fruit | 50 μg/mL | 89.80±0.007∗∗∗∗ | 91.40±0.006∗∗∗∗ | 86.12±0.004∗∗∗∗ |
Seeds | 86.02±0.004∗∗∗∗ | 84.36±0.004∗∗∗∗ | 93.68±0.006∗∗∗∗ | |
Whole fruit | 150 μg/mL | 75.25±0.005∗∗∗∗ | 76.19±0.001∗∗∗∗ | 72.46±0.005∗∗∗∗ |
Seeds | 77.95±0.002∗∗∗∗ | 77.95±0.002∗∗∗∗ | 76.08±0.004∗∗∗∗ | |
Whole fruit | 250 μg/mL | 46.27±0.003∗∗∗∗ | 64.18±0.001∗∗∗∗ | 51.35±0.005∗∗∗∗ |
Seeds | 63.04±0.003∗∗∗∗ | 61.07±0.005∗∗∗∗ | 56.02±0.02∗∗∗∗ | |
Whole fruit | 350 μg/mL | 32.60±0.007∗∗∗∗ | 54.86±0.004∗∗∗∗ | 32.40±0.005∗∗∗∗ |
Seeds | 54.76±0.002∗∗∗∗ | 50.51±0.005∗∗∗∗ | 43.78±0.003∗∗∗∗ | |
Whole fruit | 450 μg/mL | 18.32±0.004∗∗∗∗ | 25.87±0.004∗∗∗∗ | 14.59±0.005∗∗∗∗ |
Seeds | 32.09±0.003∗∗∗∗ | 36.12±0.002∗∗∗∗ | 38.01±0.004∗∗∗∗ |
Comparative cytotoxic effect of different solvent extracts of honeydew melon on HeLa cell lines after 24 h of incubation. Data is expressed as the mean ± SD (each treatment, n = 3). ∗∗∗∗ indicates p < 0.0001 in comparison with control/untreated cells by one-way ANOVA followed by Dunnett's test for multiple comparisons.