Table 5.

The comparison of genetic distributions between early/late-onset PE and control groups.

Group	N I/II	rs2027432(I)					rs4819554(I)					rs713041(II)
		CC	CT	TT	C	T	AA	AG	GG	A	G	CC	CT	TT	C	T
Early-onset PE	187/249	168	19	0	355	19	52	93	42	197	135	94	112	43	300	198
Control	457/720	79	234	144	392	522	146	230	81	522	392	204	359	157	767	673
χ 2		297.949			294.95		2.307			0.494		8.088			7.280
p		<0.001			<0.001		0.315			0.482		0.018			0.007
OR					24.881					1.096					1.329
95% CI					15.399-40.199					0.849-1.414					1.081-1.636
Late-onset PE	155/382	136	17	2	289	21	47	88	20	182	128	122	184	76	428	336
Control	457/720	79	234	144	392	522	146	230	81	522	392	204	359	157	767	673
χ 2		253.539			135.044		2.653			0.242		1.672			1.529
p		<0.001			<0.001		0.265			0.623		0.433			0.216
OR					10.335					1.068					1.118
95% CI					6.512-16.402					0.822-1.387					0.937-1.333

Table 5 shows that there existed a strong association in the genetic distributions of rs2027432 in NLRP3 between early-onset PE and control groups, late-onset PE and control groups (early-onset PE vs. control: for genotype, p < 0.001, for allele, χ² = 294.95, p < 0.001, OR = 24.881, 95%CI = 15.399‐40.199; late-onset PE vs. control: p < 0.001, for allele, χ² = 135.044, p < 0.001, OR = 10.335, 95%CI = 6.512‐16.402), while no significant differences were found in another candidate SNP rs4819554 in IL17RA (early-onset PE vs. control: for genotype, p = 0.315, for allele, χ² = 0.494, p = 0.482, OR = 1.096, 95%CI = 0.849‐1.414; late-onset PE vs. control: p = 0.265, for allele, χ² = 0.242, p = 0.623, OR = 1.068, 95%CI = 0.822‐1.387). In Table 5, it also showed that there was a strong association in the genetic distributions of rs713041 in GPX4 between early-onset PE and control groups (for genotype, p = 0.018, for allele, χ² = 7.280, p = 0.007, OR = 1.329, 95%CI = 1.081‐1.636).