Table 6.
The haplotype associations of oxidative stress-related SNPs between PE and controls.
| Freq. | PE, control ratio counts | PE, control frequencies | Chi-square | p value | |
|---|---|---|---|---|---|
| Block 1 | |||||
| GT | 0.446 | 534.0 : 728.0, 671.0 : 767.0 | 0.423, 0.467 | 5.143 | 0.0233 |
| GC | 0.443 | 592.0 : 670.0, 605.0 : 833.0 | 0.469, 0.421 | 6.373 | 0.0116 |
| AC | 0.11 | 136.0 : 1126.0, 162.0 : 1276.0 | 0.108, 0.113 | 0.164 | 0.6857 |
| Block 2 | |||||
| GG | 0.608 | 771.4 : 490.6, 871.2 : 568.8 | 0.611, 0.605 | 0.109 | 0.7414 |
| CA | 0.273 | 346.4 : 915.6, 390.2 : 1049.8 | 0.274, 0.271 | 0.041 | 0.8397 |
| CG | 0.115 | 139.6 : 1122.4, 170.8 : 1269.2 | 0.111, 0.119 | 0.418 | 0.5177 |
| Block 3 | |||||
| TG | 0.639 | 818.9 : 443.1, 908.9 : 531.1 | 0.649, 0.631 | 0.916 | 0.3385 |
| CC | 0.337 | 417.9 : 844.1, 492.9 : 947.1 | 0.331, 0.342 | 0.373 | 0.5412 |
| CG | 0.018 | 21.1 : 1240.9, 27.1 : 1412.9 | 0.017, 0.019 | 0.171 | 0.6792 |
Apparently, Table 6 indicates the haplotype associations of oxidative stress-related SNPs between PE and controls; there were two polymorphisms (rs4807542/rs713041) stated two primary haplotypes had significant difference, that is the GT and GC haplotypes from block 1, which produced the following distribution: 44.6% GT (rs4807542/rs713041), 44.3% GC, and 11% AC. Significantly statistical differences were identified in haplotype GT and GC between PE and control groups (χ2 = 5.143, p = 0.0233, p < 0.05; χ2 = 6.373, p = 0.0116, p < 0.05), while there were no differences in the rest of haplotypes.