TABLE 3.

Discrimination of inflammatory phenotypes using gene expression

	AUC	p-value	Cut-off point	Sens	Spec	PPV	NPV	Kappa
Eosinophilic asthma versus non-eosinophilic asthma
Manual plugs	0.85	0.1	0.39	56	80	71	67	0.22
Whole sample	1.00	0.01	0.99	67	100	100	77	0.72
Neutrophilic asthma versus non-neutrophilic asthma
Manual plugs	1.00	0.008	0.99	80	100	100	93	0.68
Whole sample	0.84	0.2	0.62	80	100	100	93	0.68

All measures are relative to the classification from the manual cell differential count. AUC: area under the curve; Sens: sensitivity; Spec: specificity; PPV: positive predictive value; NPV: negative predictive value; Kappa: Cohen's kappa coefficient for agreement with the gold-standard classification based on the cell differential count.