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. 2020 Feb 28;10:234. doi: 10.3389/fonc.2020.00234

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Copyright © 2020 Li, Li, Huang, Xu, Zheng, Hamsath, Zhang, Dai, Zhang, Wong, Xian, Yang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of ATTM on mRNA m⁶A methylation in A549 cells. The cells were treated with ATTM at concentrations ranging from 0 to 60 μM for 24 h. (A) The content of m⁶A mRNA was measured with a commercial kit (PC, positive control; NC, negative control). (B) The cell number was tested with CCK-8 assay. Data are presented as mean ± SD. n = 4. *P < 0.01 vs. Control group. (C) Growth of quiescent A549 cells and cells exposed to 60 μM ATTM for 24 h were captured using digital microphotograph. (D) Expressions of the m⁶A writers (METTL3, METTL14, and WTAP) and erasers (FTO and ALKBH5) were analyzed between LUAD primary tumor tissues (n = 515) and normal tissues (n = 59) in TCGA cohort. Data are showed as median ± quartile. **P < 10⁻⁴ vs. Normal tissues.