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. 2020 Feb 28;11:252. doi: 10.3389/fimmu.2020.00252

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Copyright © 2020 Borhis, Trovato, Ibrahim, Isnard, Le Grand, Bosquet and Richard.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Treatment by BR3-Fc modifies the expression of BAFF-R and TACI by spleen B-cells. Surface expression of BAFF-R (A, gMFI) and TACI (B, % of positive cells) were analyzed in every B-cell subset from 7 Placebos (white bar) and 5 Treated macaques (hatched bar). Results are presented in box-and-whiskers (5–95 percentile) plots with horizontal bars indicating median values. Statistical comparison between groups was performed using Mann Whitney non-parametric test. Significant statistical values are indicated: *p < 0.05 and **p < 0.01.