025 Haghighi 2006.

Methods	Randomised trial. Allocation concealment made by sequential sealed opaque envelope.
Participants	Inclusion criteria: women with singleton pregnancy, gestational age from 29 to 36 weeks, PPROM, parity of 2 or less, Bishop score ≤ 4, Normal FHR reactivity, absence of uterine contractions and vertex presentation. Exclusion criteria: previous uterine scar, fetal growth retardation, pre‐eclampsia, evidence of cephalopelvic disproportion, chorioamnionitis and contraindication of prostaglandin treatment.
Interventions	The intervention group received 1 25 mcg dose of misoprostol. If the contractions were not adequate in 3 hours, oxytocin augmentation was started. The comparison group received oxytocin infusion (started with 2 mcU/min and increased every 15 minutes until adequate uterine contraction).
Outcomes	There was a statistically significant difference in the interval between admittance and vaginal delivery (507.68 min ± 248.01 min in the misoprostol group vs 596.66 min ± 246.38 min in the control group; P < .005) and also in the incidence of caesarean section due to failed labour induction (9.2% in the misoprostol group vs 18.5% in the control group).
Notes	Akbarabadi Hospital in Tehran, Iran. The study run from December 2002 to May 2004. The numbers of baseline data and the neonatal outcomes were not stated.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Adequate
Allocation concealment (selection bias)	Low risk	Adequate
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Unclear
Incomplete outcome data (attrition bias) All outcomes	High risk	Adequate
Selective reporting (reporting bias)	High risk	Inadequate
Other bias	High risk	Inadequate