Comparison 5. Magnesium sulphate versus none/placebo (subgroups by dose and route of administration for maintenance therapy).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Maternal death	2	10795	Risk Ratio (M‐H, Fixed, 95% CI)	0.53 [0.26, 1.09]
1.1 Intramuscular maintenance regimen	1	4593	Risk Ratio (M‐H, Fixed, 95% CI)	0.61 [0.25, 1.48]
1.2 Intravenous maintenance regimen ‐ 1 g/hour	2	6202	Risk Ratio (M‐H, Fixed, 95% CI)	0.41 [0.12, 1.43]
1.3 Intravenous maintenance regimen ‐ 2 g/hour	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
2 Eclampsia	6	11444	Risk Ratio (M‐H, Fixed, 95% CI)	0.41 [0.29, 0.58]
2.1 Intramuscular maintenance regimen	2	4821	Risk Ratio (M‐H, Fixed, 95% CI)	0.39 [0.24, 0.65]
2.2 Intravenous maintenance regimen ‐ 1 g/hour	3	6266	Risk Ratio (M‐H, Fixed, 95% CI)	0.40 [0.24, 0.66]
2.3 Intravenous maintenance regimen ‐ 2 g/hour	2	357	Risk Ratio (M‐H, Fixed, 95% CI)	3.04 [0.13, 73.42]
3 Stillbirths and neonatal deaths	3	9961	Risk Ratio (M‐H, Fixed, 95% CI)	1.03 [0.93, 1.14]
3.1 Intramuscular maintenance regimen	2	4565	Risk Ratio (M‐H, Fixed, 95% CI)	1.01 [0.89, 1.15]
3.2 Intravenous maintenance regimen ‐ 1 g/hour	2	5396	Risk Ratio (M‐H, Fixed, 95% CI)	1.07 [0.89, 1.27]
3.3 Intravenous maintenance regimen ‐ 2 g/hour	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
4 Any reported side effects	2	10127	Risk Ratio (M‐H, Fixed, 95% CI)	5.16 [4.52, 5.89]
4.1 Intramuscular maintenance regimen	1	4553	Risk Ratio (M‐H, Fixed, 95% CI)	5.84 [4.80, 7.09]
4.2 Intravenous maintenance regimen ‐ 1 g/hour	1	5439	Risk Ratio (M‐H, Fixed, 95% CI)	4.67 [3.86, 5.66]
4.3 Intravenous maintenance regimen ‐ 2 g/hour	1	135	Risk Ratio (M‐H, Fixed, 95% CI)	3.81 [2.22, 6.53]