Kniest 1991.

Methods	Double‐blind, matched pair controlled trial
Participants	20 subjects aged 12 to 36 with house dust mite rhinitis. Divided into matched pairs on clinical and environmental parameters and then arbitrarily allocated to one of the 2 interventions.
Interventions	12 months of intensive home cleaning either with or without the addition of acaricide (solidified benzyl benzoate)
Outcomes	Daily symptoms and medication scores Physician assessment Total and mite‐specific IgE Blood and nose eosinophils Guanine exposure
Notes	—
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Unclear risk	"From each subject group, one member was arbitrarily allocated to acaricidal cleaning treatment and the other to control treatment". No further details of the randomisation technique were provided
Allocation concealment?	Unclear risk	Insufficient information
Blinding?	Low risk	"The allocation was unknown to both experimenters and subjects until the end of the study"
Incomplete outcome data addressed? All outcomes	Low risk	All outcome data reported
Free of selective reporting?	Unclear risk	Use of an unusual trial design in which matched pairs were identified and use of unusual statistical tests to modify data
Free of other bias?	Unclear risk	Patients were selected from outpatients file, so may not represent the standard population