Bernstein 1995.

Methods	Double‐blind randomised controlled trial
Participants	32 children aged 4 to 12 years with either allergic rhinitis or asthma or both and confirmed mono‐allergy to house dust mite
Interventions	Bedroom sprayed with either Acardust acaricide or placebo on days 0 and 90
Outcomes	Daily rhinitis and asthma symptom scores Medication use Twice weekly PEF Monthly clinical assessment Dust house dust mite antigen concentration at days 0, 90 and 180
Notes	—
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	Unclear risk	"The study was double‐blind, randomised, comparative, versus placebo" With respect to the use of random sequences, the technique of randomisation is not described
Allocation concealment?	Low risk	"At this entry visit, each child got the first canister (numbered with a consecutive number), containing either Acardust or Placebo ‐ both looking perfectly identical, in a randomized manner"
Blinding?	Low risk	"The study had a double‐blind, controlled manner versus placebo" design
Incomplete outcome data addressed? All outcomes	Unclear risk	"Out of the 35 children there were 3 drop‐outs for lack of compliance (1 in the Acardust group, 2 in the placebo group)". However, they appear not to have undertaken an intention‐to‐treat analysis
Free of selective reporting?	Low risk	No evidence of selective reporting
Free of other bias?	Low risk	No evidence of other bias