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BEAT detected an increased editing efficiency of codon-optimized ABEmax compared with the original ABE7.10. (A–C) Sanger sequencing data of PCR products from HEK293 cells transfected with irrelevant plasmid control (A), ABE7.10 plus sgRNA targeting Site2 (B), or ABEmax plus sgRNA targeting Site2 (C). (D) A higher rate of A-to-G conversion at position 5 was detected in cells transfected with ABEmax. **p < 0.01.
