Table 5.
Associations of daily phone call on the risk of thyroid cancer in populations stratified by SNP variants
| Gene | SNP | Cell phone non-user |
Daily phone call |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤5 calls/day |
>5 calls/day |
P value for trend | |||||||||
| Case | Control | ORa (95% CI) | Case | Control | ORa (95% CI) | Case | Control | ORa (95% CI) | |||
| PAK6 | rs11070256 | ||||||||||
| AA | 33 | 59 | 1.00 | 123 | 128 | 0.70 (0.43–1.15) | 74 | 85 | 0.58 (0.33–1.01) | 0.0572 | |
| AC/CC | 11 | 53 | 1.00 | 73 | 83 | 1.82 (0.96–3.44) | 51 | 40 | 3.12 (1.53–6.37) | 0.0016 | |
| MDM2 | rs1695147 | ||||||||||
| AA | 31 | 69 | 1.00 | 124 | 150 | 0.75 (0.48–1.18) | 74 | 85 | 0.72 (0.43–1.20) | 0.2249 | |
| AC/CC | 13 | 43 | 1.00 | 71 | 60 | 2.25 (1.11–4.57) | 51 | 40 | 2.97 (1.38–6.40) | 0.0076 | |
| HDAC4 | rs6732673 | ||||||||||
| TT | 20 | 33 | 1.00 | 62 | 73 | 0.61 (0.31–1.17) | 47 | 49 | 0.66 (0.32–1.36) | 0.3208 | |
| TC/CC | 24 | 80 | 1.00 | 134 | 138 | 1.52 (0.94–2.44) | 76 | 75 | 1.59 (0.93–2.74) | 0.1102 | |
| HDAC4 | rs1063639 | ||||||||||
| GG | 13 | 14 | 1.00 | 41 | 55 | 0.29 (0.12–0.69) | 34 | 24 | 0.53 (0.20–1.41) | 0.4384 | |
| GA/AA | 31 | 98 | 1.00 | 155 | 155 | 1.46 (0.95–2.24) | 91 | 100 | 1.35 (0.84–2.18) | 0.2638 | |
| HDAC4 | rs843458 | ||||||||||
| AA | 25 | 73 | 1.00 | 61 | 73 | 0.69 (0.37, 1.27) | 35 | 50 | 0.63 (0.31, 1.25) | 0.7835 | |
| AC/CC | 19 | 40 | 1.00 | 135 | 138 | 1.47 (0.90, 2.38) | 90 | 75 | 1.69 (0.98, 2.93) | 0.3263 | |
| GATA4 | rs3757949 | ||||||||||
| GG | 19 | 78 | 1.00 | 76 | 97 | 0.56 (0.30, 1.03) | 51 | 54 | 0.65 (0.33, 1.29) | 0.4335 | |
| GC/CC | 24 | 35 | 1.00 | 119 | 112 | 1.72 (1.05, 2.81) | 73 | 70 | 1.67 (0.97, 2.89) | 0.6795 | |
| UBE2V1 | rs6125888 | ||||||||||
| TT | 34 | 100 | 1.00 | 39 | 47 | 0.46 (0.19, 1.11) | 25 | 35 | 0.45 (0.18, 1.13) | 0.8957 | |
| TG/GG | 10 | 13 | 1.00 | 157 | 163 | 1.34 (0.88, 2.04) | 100 | 90 | 1.52 (0.95, 2.43) | 0.3572 | |
| LINC00336 | rs396746 | ||||||||||
| AA | 35 | 82 | 1.00 | 144 | 163 | 0.83 (0.55–1.27) | 88 | 102 | 0.83 (0.52–1.34) | 0.4731 | |
| AC/CC | 9 | 31 | 1.00 | 52 | 48 | 2.43 (1.01–5.86) | 37 | 23 | 3.81 (1.45–10.0) | 0.0077 | |
| DACT2 | rs12204529 | ||||||||||
| CC | 36 | 72 | 1.00 | 133 | 156 | 0.70 (0.44–1.10) | 90 | 87 | 0.88 (0.53–1.46) | 0.7812 | |
| CG/GG | 8 | 40 | 1.00 | 62 | 55 | 2.95 (1.43–6.08) | 35 | 38 | 2.00 (0.89–4.49) | 0.1301 | |
| DACT2 | rs3800537 | ||||||||||
| AA | 38 | 75 | 1.00 | 141 | 157 | 0.75 (0.48–1.18) | 90 | 88 | 0.91 (0.55–1.49) | 0.8120 | |
| AG/GG | 6 | 38 | 1.00 | 55 | 54 | 2.97 (1.38–6.35) | 35 | 37 | 2.07 (0.90–4.76) | 0.1304 | |
a
adjusted for age (continuous), sex (male, female), education (<college, college, >college), family history of thyroid cancer (yes, no), alcohol consumption (yes, no), body mass index (BMI, <25, 25–29.9, ≥30), and previous benign thyroid diseases (yes, no).