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. 2020 Mar 9;16(3):e9275. doi: 10.15252/msb.20199275

Figure EV6. Differential methylation and copy number between healthy and tumor samples of tRNA genes, related to Fig 5 .

Figure EV6

  1. Differential average methylation (bisulfite sequencing) for the isoacceptors, averaged over all genes that have a certain anticodon. The difference is measured by Δ%Me = (%MeTumor‐%MeHealthy). Refer to Table EV4 for full cancer type names and number of samples.
  2. Differential average gene copy number for the isoacceptors, averaged over all genes that have a certain anticodon. The difference is measured by ΔCNA = (CNATumor‐CNAHealthy). Only significant differences are colored, which are determined using a two‐tailed Wilcoxon rank‐sum test and corrected for multiple testing by FDR.
  3. Differential gene copy number between healthy and tumor samples of genes expressing proline tRNAs, as measured by ΔCNA. Only significant differences are colored, which are determined using a two‐tailed Wilcoxon rank‐sum test and corrected for multiple testing by FDR.