Figure 3. Cluster analysis of TNFRSF10B, TNFRSF10C, TP53TG5, MDM2, BAX, BCL-2 and CASPASE-8 genes in the TOV-21G and the SKOV-3 cells treated with cisplatin or rhTRAIL alone, or in combination. Following cisplatin treatment, TP53TG5 was up-regulated in both cell lines, while CASPASE-8 was up-regulated in the TOV-21G cells. Following rhTRAIL treatment, CASPASE-8 and TNFRSF10B up-regulation was observed in the SKOV-2 cells and CASPASE-8 up-regulation was observed in the TOV-21G cells. Combined cisplatin-rhTRAIL treatment up-regulated CASPASE-8 in the TOV-21G cells.
