Comparison 1. 01 Pentoxifylline (Overall).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 01 Healing or significant improvement	11	841	Risk Ratio (M‐H, Random, 95% CI)	1.70 [1.30, 2.24]
2 Sensitivity analysis: excluding open or single blind studies	9	737	Risk Ratio (M‐H, Fixed, 95% CI)	1.60 [1.38, 1.85]
3 Sensitivity analysis: excluding trials with short treatment duration	6	693	Risk Ratio (M‐H, Fixed, 95% CI)	1.55 [1.34, 1.80]
4 Sensitivity analysis: excluding trials that did not report healing only as an outcome	9	751	Risk Ratio (M‐H, Fixed, 95% CI)	1.56 [1.34, 1.80]
5 Sensitivity analysis: excluding trials not using compression	7	659	Risk Ratio (M‐H, Fixed, 95% CI)	1.51 [1.30, 1.76]
6 Sensitivity analysis: excluding trials that recruited hard‐to‐heal patients only	7	517	Risk Ratio (M‐H, Fixed, 95% CI)	1.30 [1.10, 1.54]
7 Side effects	9	629	Risk Ratio (M‐H, Fixed, 95% CI)	1.56 [1.10, 2.22]