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. 1999 Apr 26;1999(2):CD000948. doi: 10.1002/14651858.CD000948

Spitzer 1982.

Methods Allocation concealment ‐ can't tell. 
 Randomization into blocks of two in order to stratify according to birth weight. The intervention was randomized for the first infant entering into a birth weight category and the next infant received the other intervention. 
 Blinding of intervention ‐ no. 
 Completeness of follow‐up ‐ no, as 14 additional infants were excluded because of early death or because they required ventilation for <48 hours. 
 Blinding of outcome ‐ no.
Participants Analysis resulted in 86 newborn infants requiring ventilation for >48 hours. 
 Stratified into weight groups >3000 gram and 3000 gram and less divided into 500 grams groups
Interventions Endotracheal intubation by either nasal or oral route
Outcomes Tube blockage 
 Pneumothorax 
 Post extubation atelectasis reported by weight groups 
 Re‐intubation 
 Local trauma
Notes The focus of the study was on post‐extubation atelectasis
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear