| Methods |
Randomised, placebo controlled trial
Blinding of randomisation:‐ Can't tell
Blinding of intervention:‐ No
Blinding of outcome assessors:‐No
Complete follow up:‐Yes |
| Participants |
Number entered into study =20, 10 in each group
Inclusion criteria=
birth weight 1001‐1500g requiring parenteral nutrition. Exclusion criteria=not expected to survive, recent blood transfusion, not expected to require parenteral nutrition for more than 1 week. |
| Interventions |
50 micromol/kg/day carnitine as a continuous intravenous infusion vs placebo until >50% of caloric intake was enteral.
Parenteral lipid was started at 0.5g/kg/day and increased gradually if serum triglyceride level was <1.7mmol/l |
| Outcomes |
Outcomes were reported at 2 weeks of study. Weight gain in g/day
Beta hydroxybutyrate levels (weekly)
Serum carnitine (weekly)
Mean quantity of lipid tolerated daily.
Triglyceride levels |
| Notes |
Same trial as Bonner 1995a |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
Unclear risk |
B ‐ Unclear |
