| Methods |
Randomised controlled trial
Blinding of randomisation:‐Can't tell
Blinding of intervention:‐Yes
Blinding of outcome assessors:‐Cant tell
Complete follow up:‐Yes |
| Participants |
Number entered into study =12, 6 in each group
Inclusion criteria
Newborn undergoing major surgery in first few days of life and expected to require parenteral support for at least 1 week.
No exclusions stated |
| Interventions |
70 micromol/kg/day carnitine or placebo in divided doses every 3 hours enterally for 7 days |
| Outcomes |
Weight gain
Plasma taken on days 1 and 8 for free fatty acids, triglycerides, total ketone bodies and carnitine. |
| Notes |
Biochemical results obtained after a short lipid challenge (0.5g/kg intralipid over 2 hours) at 2,4,6 and 8 hours |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
Unclear risk |
B ‐ Unclear |
