| Methods |
Randomised, placebo controlled trial
Blinding of randomisation:‐ Can't tell
Blinding of intervention:‐ No
Blinding of outcome assessors:‐No
Complete follow up:‐Yes |
| Participants |
Number entering study=15, 7 in the carnitine group
Inclusion criteria =appropriately grown neonates, 34‐37 weeks
gestational age and 1200‐2490g birth weight
requiring parenteral nutrition
Exclusions=severe jaundice, sepsis, metabolic disturbance or intracerebral haemorrhage |
| Interventions |
60 micromol/kg/day IV carnitine infused over 5 hours while on parenteral nutrition. Control group not supplemented, the use of placebo is not stated. |
| Outcomes |
An intravenous lipid challenge was carried out on days 6‐10 before the start of enteral feeds Plasma was taken for ‐ Betahydroxybutyrate,
triglycerides, free fatty acids and carnitine |
| Notes |
Biochemical results obtained after a lipid challenge (1g/kg Intralipid over 4 hours)
Same trial as Schmidt‐S. 1983a |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
Unclear risk |
B ‐ Unclear |
