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. 2005 Jul 20;2005(3):CD000345. doi: 10.1002/14651858.CD000345.pub2

Comparison 9. Gluco+IFN versus Control+IFN (trials stratified according to length of follow‐up).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Loss of HBeAg 13   Peto Odds Ratio (Peto, Fixed, 95% CI) Subtotals only
1.1 End of treatment 5 201 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.10 [0.58, 2.10]
1.2 Six months after the end of treatment 4 257 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.98 [0.57, 1.69]
1.3 More than six months after the end of treatment 8 538 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.51 [1.05, 2.17]
2 HBeAg to anti‐HBe seroconversion 8   Peto Odds Ratio (Peto, Fixed, 95% CI) Subtotals only
2.1 End of treatment 2 79 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.20 [0.45, 3.16]
2.2 Six months after the end of treatment 3 178 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.99 [0.53, 1.87]
2.3 More than six months after the end of treatment 5 390 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.49 [0.94, 2.37]
3 Loss of HBsAg 11   Peto Odds Ratio (Peto, Fixed, 95% CI) Subtotals only
3.1 End of treatment 1 50 Peto Odds Ratio (Peto, Fixed, 95% CI) 2.67 [0.35, 20.21]
3.2 Six months after the end of treatment 4 195 Peto Odds Ratio (Peto, Fixed, 95% CI) 0.39 [0.13, 1.17]
3.3 More than six months after the end of treatment 7 462 Peto Odds Ratio (Peto, Fixed, 95% CI) 2.72 [1.23, 6.04]
4 Loss of HBV DNA 13   Peto Odds Ratio (Peto, Fixed, 95% CI) Subtotals only
4.1 End of treatment 5 200 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.52 [0.82, 2.83]
4.2 Six months after the end of treatment 4 428 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.71 [1.11, 2.63]
4.3 More than six months after the end of treatment 8 340 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.37 [0.86, 2.17]
5 Normalisation of ALT or AST activities 9   Peto Odds Ratio (Peto, Fixed, 95% CI) Subtotals only
5.1 End of treatment 3 131 Peto Odds Ratio (Peto, Fixed, 95% CI) 2.23 [1.12, 4.43]
5.2 Six months after the end of treatment 2 285 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.02 [0.57, 1.81]
5.3 More than six months after the end of treatment 5 243 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.13 [0.67, 1.90]