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. 2020 Mar 4;13:1921–1929. doi: 10.2147/OTT.S223542

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© 2020 Yuan et al.

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Overexpression of hsa_circ_0068033 induced apoptosis in MCF-7 and MDA-MB-231 cells. (A) The TUNEL assay showed increasing apoptosis in MCF-7 and MDA-MB-231 cells following the overexpression of hsa_circ_0068033. Apoptotic cells were counted 72 h following transfection. (B) DNA ladder assay. Images were captured 72 h following transfection with PLCDH-cirR0068033. (C, D) Immunoblotting showed activation of the intrinsic apoptotic proteins Bcl-2 and procaspase-3 in the two cell lines in response to overexpression of hsa_circ_0068033. *P<0.05, **P<0.01.