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. 2020 Mar 4;13:1909–1919. doi: 10.2147/OTT.S241632

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© 2020 Wang et al.

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Berberine (BBR) reverses doxorubicin (ADR) resistance in vivo. (A) ADR-resistant MCF-7 (MCF-7/ADR) cells were subcutaneously injected into BALB/C nude female mice to establish a xenograft tumor model. (B) A combination of BBR and ADR significantly inhibited tumor growth in vivo. (C) Tumor volumes were measured every 3 days. The results showed that BBR treatment significantly inhibited tumor growth in vivo. (D) Body weight was measured every 3 days. The results showed that BBR and/or ADR treatment did not affect body weight in vivo. (E) Western blotting analysis of extracted tumor tissues showed that BBR treatment inhibited the expression of PTEN and LC3II/I and increased Akt phosphorylation levels (BBR, 10 mg/kg; ADR, 4 mg/kg). N/A, not significant; ***p<0.001 (Student’s t-test).