Table 3.
Characteristics of the Study Participants with Regard to the Association of Microbial Metabolites with Lymph Node Metastasis
| N0 | N1 | N2 | X2/F value | p value | |
|---|---|---|---|---|---|
| Cases, n | 18 | 15 | 15 | – | – |
| Rectal cancer, n | 7 | 4 | 7 | 1.30 | 0.521 |
| Males, n | 15 | 10 | 11 | 1.24 | 0.537 |
| Age, years | 62.50±9.12 | 59.40±11.30 | 64.33±10.67 | 0.88 | 0.423 |
| Long-term Smoking history, n | 4 | 3 | 2 | 0.45 | 0.800 |
| Long-term drinking history, n | 3 | 4 | 2 | 0.96 | 0.620 |
| Known diabetes, n | 1 | 0 | 2 | 2.30 | 0.317 |
| Known hypertension, n | 8 | 5 | 10 | 3.48 | 0.176 |
| Glutamic oxaloacetic transaminase, U/L | 31.67±15.61 | 32.66±20.02 | 33.16±20.63 | 0.03 | 0.973 |
| Alanine transaminase, U/L | 27.15±19.50 | 17.59±12.49 | 16.63±9.10 | 2.62 | 0.084 |
| Albumin, g/L | 38.19±7.28 | 38.61±4.38 | 37.26±4.71 | 0.22 | 0.805 |
| Creatinine, μmol/L | 71.01±15.88 | 66.65±10.98 | 73.21±17.21 | 0.75 | 0.480 |
| FBG(fasting blood-glucose), mmol/L | 4.93±1.18 | 4.99±0.78 | 5.43±0.94 | 1.19 | 0.314 |
| Triglyceride, mmol/L | 1.57±0.80 | 1.27±0.36 | 1.36±0.72 | 0.90 | 0.414 |
| Total cholesterol, mmol/L | 5.016±1.14 | 4.75±0.80 | 4.52±1.02 | 1.02 | 0.370 |
| Carbohydrate antigen 153, U/mL | 11.47±5.63 | 11.11±3.41 | 11.16±4.63 | 0.03 | 0.971 |
| Carbohydrate antigen 724, U/mL | 22.85±31.10 | 30.11±32.26 | 15.93±19.62 | 0.93 | 0.402 |
| Carbohydrate antigen 199, U/mL | 417.30±1370.62 | 26.88±43.99 | 10.95±14.67 | 1.26 | 0.294 |
| Carcinoembryonic antigen, ng/mL | 78.86±144.75 | 19.37±31.68 | 6.32±9.17 | 3.05 | 0.057 |
Note: Overall, 48 CRC patients were recruited in the microbial metabolomics study. The clinical stages conformed according to AJCC. Smoking and drinking history over the course of 1 year were collected. The table shows the clinical characteristics of these participants. There was no significant difference between the patients with different lymph node metastasis status in regards to site, age, sex, smoking, drinking history and serological indicator such as glutamic oxaloacetic transaminase, alanine transaminase, albumin, creatinine, FBG, triglycerides, total cholesterol, carbohydrate antigen 153, carbohydrate antigen 742, carbohydrate antigen 199, and carcino embryonic antigen.