Table 1:
Baseline patient characteristics in the PET and SPECT MPI groups
| PET MPI (N=161) | SPECT MPI (N=161) | p-value | |
|---|---|---|---|
| Patient characteristics | |||
| Age, years | 66.5 ± 9.4 | 66.1 ± 10.0 | 0.75 |
| Male gender | 101 (62.7%) | 108 (67.1%) | 0.41 |
| Body mass index, kg/m2 | 28.8 ± 4.5 | 29.2 ± 5.2 | 0.50 |
| Employment Status | 0.77 | ||
| Disabled | 17 (10.6%) | 17 (10.6%) | |
| Retired | 85 (53.1%) | 92 (57.5%) | |
| Full time employed | 43 (26.9%) | 41 (25.6%) | |
| Part time employed | 11 (6.9%) | 6 (3.8%) | |
| Unemployed | 4 (2.5%) | 4 (2.5%) | |
| Hypertension | 139 (86.34%) | 150 (93.17%) | 0.04 |
| Diabetes | 43 (26.7%) | 46 (28.6%) | 0.14 |
| Hyperlipidemia | 160 (99.38%) | 160 (99.38%) | 1.0 |
| Smoker | 27 (16.77%) | 32 (19.88%) | 0.47 |
| Family history of CVD | 66 (40.99%) | 74 (45.96%) | 0.37 |
| Cerebrovascular Accident | 24 (14.91%) | 25 (15.53%) | 0.88 |
| Peripheral Vascular Disease | 43 (26.71%) | 43 (26.71%) | 1.0 |
| Atrial Fibrillation | 32 (19.88%) | 19 (11.80%) | 0.05 |
| Hospital Status at time of MPI | 0.18 | ||
| Inpatient | 1 (0.62%) | 4 (2.48%) | |
| Outpatient | 160 (99.38%) | 157 (97.52%) | |
| Abnormal Baseline EKG | 72 (44.72%) | 63 (39.13%) | 0.31 |
| Symptoms | |||
| Chest Pain | 0.30 | ||
| Typical | 60 (44.1%) | 45 (36.0%) | |
| Atypical | 40 (29.4%) | 47 (37.6%) | |
| Non-anginal | 36 (26.5%) | 33 (26.4%) | |
| Dyspnea | 106 (65.8%) | 114 (70.8%) | 0.34 |
| Syncope | 5 (3.1%) | 5 (3.1%) | 1.0 |
| Baseline Medications | |||
| Aspirin | 144 (89.4%) | 142 (88.2%) | 0.72 |
| Other Antiplatelets | 58 (36.0%) | 54 (33.5%) | 0.64 |
| Beta-blockers | 122 (75.8%) | 125 (77.6%) | 0.69 |
| Calcium channel blockers | 31 (19.3%) | 30 (18.6%) | 0.89 |
| Nitrates | 74 (46.0%) | 86 (53.4%) | 0.18 |
| Statins | 127 (78.9%) | 122 (75.8%) | 0.51 |
| Ranolazine | 1 (0.6%) | 3 (1.9%) | 0.31 |
| ACEI/ARB | 98 (60.9%) | 99 (61.5%) | 0.91 |
| No of anti-anginals at baseline | 0.62 | ||
| 0 | 2 (1.2%) | 0 (0.0%) | |
| 1 | 5 (3.1%) | 7 (4.4%) | |
| 2 | 30 (18.6%) | 27 (16.8%) | |
| 3 | 66 (41.0%) | 65 (40.4%) | |
| ≥4 | 58 (36.0%) | 62 (38.5%) | |
| Stress testing characteristics | |||
| Rest Heart Rate, bpm | 64.7 ± 11.3 | 64.9 ± 11.3 | 0.90 |
| Rest Systolic Blood Pressure, mmHg | 131.9 ± 20.0 | 130.5 ± 20.5 | 0.52 |
| Stress Heart Rate, bpm | 85.8 ± 17.7 | 82.8 ± 17.8 | 0.13 |
| Stress Systolic Blood Pressure, mmHg | 122.8 ± 19.9 | 122.0 ± 20.1 | 0.74 |
| ECG Response | 0.35 | ||
| Non-ischemic | 123 (76.4%) | 117 (72.7%) | |
| Ischemic | 18 (11.2%) | 14 (8.7%) | |
| Equivocal | 0 (0.0%) | 1 (0.6%) | |
| Non-diagnostic | 20 (12.4%) | 29 (18.0%) | |
| MPI findings | |||
| Rest LVEF, % | 59 ± 12 | 65 ± 16 | <.001 |
| Stress LVEF, % | 62 ± 11 | 66 ± 14 | 0.003 |
| Summed Rest Score (median) | 0 (0, 0) | 0 (0, 1) | 0.06 |
| No ischemia | 94 (58.4%) | 95 (59.0%) | 0.09 |
| Mild ischemia | 11 (6.8%) | 14 (8.7%) | |
| Moderate ischemia | 23 (14.3%) | 31 (19.3%) | |
| Severe ischemia | 32 (19.9%) | 17 (10.6%) | |
| Non-diagnostic | 1 (0.6%) | 4 (2.5%) | |
| LAD ischemia* | 41 (25.5%) | 43 (26.7%) | 0.80 |
| LCX ischemia* | 31 (19.3%) | 32 (19.8%) | 0.89 |
| RCA ischemia* | 32 (21.1%) | 39 (24.2%) | 0.51 |
p-values obtained using chi-square test or Fisher-exact test for categorical variables and t-test or Wilcoxon Rank Sum (Summed Rest Score) for continuous variables. PET= Positron Emission Tomography, SPECT= Single Photon Emission Computed Tomography, MPI= Myocardial Perfusion Imaging, ACEI= Angiotensin Converting Enzyme Inhibitor, ARB= Angiotensin Receptor Blocker, LVEF= left ventricular ejection fraction. LAD= left anterior descending, LCX= left circumflex, RCA= right coronary artery.
*
there may be overlap between different vascular territories