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. 2020 Mar 9;20:85. doi: 10.1186/s12883-020-01662-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Correlation of serum and exosome α-synuclein with measures of disease severity in epilepsy and acquired demyelinating disorders of CNS. (a-b) Mean α-synuclein levels from serum (a) and exosomal extracts (b) in patients with epilepsy (N = 115), acquired demyelinating disorders of the central nervous system (N = 18) and controls (N = 146). Acquired demyelinating disorders of the central nervous system include acute disseminated encephalomyelitis, neuromyelitis optica spectrum disorder, multiple sclerosis and transverse myelitis. (a) Mean serum α-synuclein levels showed significant differences in patients with epilepsy and acquired demyelinating disorders of the CNS compared to controls (p = 0.0103). (b) Serum α-synuclein levels showed a significant positive correlation with the number of antiepileptic drugs used by epilepsy patients (p = 0.0222, r = 0.2132). (c) Serum α-synuclein levels showed a significant positive correlation with the duration of disease in patients with acute demyelinating disorders of the CNS (p = 0.0374, r = 0.5892). (d) Mean exosomal α-synuclein levels were not significantly different in patients with epilepsy or acquired demyelinating disorders of the central nervous system compared to controls (p = 0.2341). (e-f) Correlation of exosome α-synuclein levels with serum α-synuclein levels (e) and with serum IL-6 levels (f) in combined groups of patients with epilepsy (N = 115) plus patients with acquired demyelinating disorders of the CNS (N = 18) and controls (N = 146). (e) Exosome α-synuclein levels showed a significant correlation with serum α-synuclein positively (p < 0.0001, r = 0.5915). (f) Exosomal α-synuclein levels showed significant correlation with serum IL-6 levels positively (p = 0.0334, r = 0.1349). Ds, disorders; No, numbers; AED, antiepileptic drugs; CNS, central nervous system; IL, interleukin