Viladomiu 1992.

Methods	Randomisation: yes Blinding: no Intention to treat: yes Methodological score: 7
Participants	‐ Patients with acute hepatitis C ‐ n = 28 ‐ Arms (IFN/C): 15/13 ‐ RNA + at entry: NDA ‐ Excluded: 0/0 ‐ Mean age (y): 54/51 ‐ Male (%): 60/70 ‐ Transfusion (%): 100/100 ‐ Drug abuse (%) : 0/0 ‐ Genotype: NDA ‐ Mean disease duration (wk): 7/7
Interventions	‐ Schedule: Control: no intervention Experimental: IFN alpha‐2b 3 MU tiw x 3 mo ‐ F/U: 9 mo
Outcomes	‐ Biochemical ETR and SR ‐ Liver histology ‐ Adverse events
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	B ‐ Unclear

C: control 
 IFN: interferon 
 NDA: no data available. 
 ETR: end of treatment response. 
 SR: sustained response. 
 wk: weeks 
 mo: months 
 y: years 
 MU: million units 
 tiw: three times weekly