Craxi 1996.
Methods | Allocation concealment: adequate (sealed envelopes). Blinding: no. Intention to treat: yes. Methodological score: 18. | |
Participants | NAIVE PATIENTS WITH CHRONIC HEPATITIS C Arms: 56/60 Excluded: 13/10 Mean age: 48/47 % males: 86/78 % transfusion: 100/100 % drug abuse: 0/0 % cirrhosis: 36/37 Genotypes: G1 (86/91), G2,3 (14/9) Disease duration: 4/5 | |
Interventions | Experimental 1: Alfa‐n‐1 IFN 5 MU/m2 TIW x 2mo; 3 MU/m2 TIW x 10 mo Experimental 2: Alfa‐n‐1 IFN 5 MU/m2 TIW x 2mo; 3 MU/m2 TIW x 4 mo Follow‐up: 12 mo |
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Outcomes | ‐ biochemical ETR and SR ‐ virologic ETR and SR | |
Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment? | Low risk | A ‐ Adequate |