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. 2002 Apr 22;2002(2):CD000370. doi: 10.1002/14651858.CD000370

Craxi 1996.

Methods Allocation concealment: adequate (sealed envelopes). 
 Blinding: no. 
 Intention to treat: yes. 
 Methodological score: 18.
Participants NAIVE PATIENTS WITH CHRONIC HEPATITIS C 
 Arms: 56/60 
 Excluded: 13/10 
 Mean age: 48/47 
 % males: 86/78 
 % transfusion: 100/100 
 % drug abuse: 0/0 
 % cirrhosis: 36/37 
 Genotypes: G1 (86/91), G2,3 (14/9) 
 Disease duration: 4/5
Interventions Experimental 1: Alfa‐n‐1 IFN 5 MU/m2 TIW x 2mo; 3 MU/m2 TIW x 10 mo
Experimental 2: Alfa‐n‐1 IFN 5 MU/m2 TIW x 2mo; 3 MU/m2 TIW x 4 mo
Follow‐up: 12 mo
Outcomes ‐ biochemical ETR and SR 
 ‐ virologic ETR and SR
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Low risk A ‐ Adequate