Farrell 1998.

Methods	Allocation concealment: adequate (centralized computer). Blinding: no. Intention to treat: yes. Methodological score: 18.
Participants	NAIVE PATIENTS WITH CHRONIC HEPATITIS C Arms: 533/538 Excluded: 26/19 Mean age: 39/39 % males: 69/69 % transfusion: NDA % drug abuse: NDA % cirrhosis: 53/59 Genotypes: G1 (60/62%), G2,3 (34/34%), other (6/4%) Disease duration: NDA
Interventions	Experimental 1: Alfa‐n‐1 IFN 3 MU TIW x 6 mo Experimental 2 : Alfa‐2b IFN 3 MU TIW x 6 mo Follow‐up: 12 mo
Outcomes	‐ biochemical ETR and SR ‐ virologic ETR and SR
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate