Hagiwara 1993.

Methods	Allocation concealment: unclear. Blinding: no. Intention to treat: no. Methodological score: 10.
Participants	NAIVE PATIENTS WITH CHRONIC HEPATITIS C Arms: 30/30 Excluded: 3/4 Mean age: 47/49 % males: 82/65 % transfusion: 22/42 % drug abuse: NDA % cirrhosis: NDA Genotypes: NDA Disease duration: NDA
Interventions	Experimental 1: Alfa‐n‐1 IFN 6 MU/day x 2 wk; 6 MU TIW x 6 mo Experimental 2: Alfa‐n‐1 IFN 3 MU/day x 2 wk; 3 MU TIW x 6 mo Follow‐up: 6 mo
Outcomes	‐ biochemical ETR and SVR ‐ virologic ETR and SR
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	B ‐ Unclear