Poynard 1995.

Methods	Allocation concealment: adequate (sealed envelopes). Blinding: no. Intention to treat: yes. Methodological score: 16.
Participants	NAIVE PATIENTS WITH CHRONIC HEPATITIS C Arms: 103/99/101 Excluded: 31/0/0 Mean age: 49/50/51 % males: 51/49/55 % transfusion: 52/47/45 % drug abuse: NDA % cirrhosis: 27/23/27 Genotypes : NDA Disease duration: 6/7/9
Interventions	Experimental 1: Alfa‐2b IFN 3MU TIW x 18 mo Experimental 2: Alfa‐2b IFN 3MU TIW x 6 mo Experimental 3: Alfa‐2b IFN 3MU TIW x 6mo; 1MU TIW x 12 mo Follow‐up: 24 mo
Outcomes	‐ biochemical ETR and SR ‐ virologic SR
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate