Valla 1999.

Methods	Allocation concealment: adequate (centralized randomisation; table of random numbers). Blinding: no. Intention to treat: yes. Methodological score: 16.
Participants	NAIVE PATIENTS WITH CHRONIC HEPATITIS C Arms: 47/52 Excluded: 10/13 Mean age: 57/56 % males: 70/61 % transfusion: 36/36 % drug abuse: 4/6 % cirrhosis: 100/100 Genotypes: G1 (50/63%), G2,3 (42/29), other (8/8%) Disease duration: 9/11
Interventions	Experimental: Alfa‐2b IFN 3 MU TIW x 6 mo Control: no intervention. Ten patients received IFN treatment after follow‐up wk 72. Follow‐up: 12 mo
Outcomes	‐ biochemical ETR and SR ‐ incidence of hepatocellular carcinoma
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate