Villa 1996 (leu‐IFN).

Methods	Allocation concealment: adequate (centralized computer). Blinding: yes. Intention to treat: yes. Methodological score: 16.
Participants	NAIVE PATIENTS WITH CHRONIC HEPATITIS C Arms: 20/19/21 Excluded: 1/1/1 Mean age: 46/41/45 % males: 70/79/71 % transfusion: 5/11/10 % drug abuse: 10/10/5 % cirrhosis: 7/7/3 Genotypes: NDA Disease duration: NDA
Interventions	Experimental 1: Alfa‐n3 IFN 3 MU TIW x 6 mo Experimental 2: Beta‐IFN 3 MU TIW x 6 mo Experimental 3: Alfa‐2b IFN 3 MU TIW x 6 mo Follow‐up: 30 mo
Outcomes	‐ biochemical ETR and SR ‐ virologic ETR and SR
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate