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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Trends Neurosci. 2019 Jun;42(6):425–437. doi: 10.1016/j.tins.2019.03.001

Figure 2: Spatial organization of release sites in the active zone.

Figure 2:

(A) SMLM-based functional measurements of individual vesicle fusion events in hippocampal synapses revealed multiple clusters or release events representing distinct release sites within individual AZs, with ~90nm between clusters (data modified with permission from ref [46]). (B) PALM and STORM measurements revealed that nanoclusters of presynaptic docking factors (RIM1/2) align trans-synaptically with nanoclusters of post-synaptic proteins (PSD95) (data reproduced with permission from ref [16]). (C) Cartoon representation of trans-synaptic alignment of functionally defined presynaptic release sites, nanoclusters of presynaptic docking factors and nanoclusters of post-synaptic proteins, such as PSD95. Protein cluster-to-cluster distances are similar to release site distances in (A).