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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Trends Neurosci. 2019 Jun;42(6):425–437. doi: 10.1016/j.tins.2019.03.001

Figure 3: Synaptic vesicle dynamics during recycling and release site replenishment.

Figure 3:

(A) Single-vesicle tracking of recycling synaptic vesicles revealed complex dynamical patterns of mobility with multiple types of motion inside synaptic boutons and along the axon (data reproduced with permission from ref [81]). (B) SMLM-based analysis of individual vesicle trajectories revealed that vesicle dynamics inside synaptic boutons is activity-dependent (data reproduced with permission from ref [69]). (C) SMLM-based tracking of single Q-dot labeled vesicles in hippocampal synapses showed that synaptic vesicle mobility toward the AZ depends on vesicle initial localization within the bouton (data reproduced with permission from ref [50]). (D) Cartoon representation of synaptic vesicle recycling and its dynamic modulation. During the recycling process, vesicle mobility inside the synaptic boutons is supported, in part, by actin and myosin motors, and is rapidly modulated by neural activity. Vesicle retention at the release sites is myosin V- and activity-dependent. Synaptic vesicles are also exchanged among synaptic boutons via an actin/myosin V-dependent inter-synaptic vesicle exchange (ISVE), which is dynamically regulated by neural activity.