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. 2020 Mar 2;10:1388. doi: 10.3389/fgene.2019.01388

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Copyright © 2020 Yu, Liu, Chen and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diagram of the core gene regulatory network containing six nodes and 16 regulations (seven activations and nine repressions; arrows represent activating regulations, short bars represent repressing regulations). Diamond-shaped nodes represent microRNAs. Round orange nodes represent specific cancer genes, violet node represents the specific EMT gene, blue represents the specific CSC gene. Parameters: k ₁ = k ₂ = 1, λ_a = 8, λ_r = 0.5, h_a = 2, h_r = 1.875, g ₀ = 50, f = k ∗ ω.