Fig. 12.

Janus particles as biosensor for biomolecules detection. (Aa) Schematic illustration of the peroxidase-like activity of JFSNs in catalysis of the TMB-H₂O₂ system and using GOx-JFSNs as biosensing platform for colorimetric detection of H₂O₂ and glucose, (Ab) TEM image of JFSNs, (Ac) determination of the selectivity of glucose detection with glucose, no saccharide, fructose lactose, maltose, and lactose (inset: photograph showing colorimetric responses of the system), (Ad) catalytic activity of glucose in buffer and in 10–50% fetal bovine serum. Reproduced with permission from Ref. [164]. Copyright 2015, American Chemical Society. (Ba) Schematic illustration of a typical light path in retroreflection, (Bb) SEM image of the isolated single RJP, (Bc) results of retroreflective cTnI immunoassay utilizing cTnI antibody-conjugated SMJPs, (Bd) dose-response curve for number of SMJPs in the square-patterned gold immunosensing zone as a function of cTnI concentration. Reproduced with permission from Ref. [33]. Copyright 2016, American Chemical Society.