8. Summary of Quality of Life (QOL): Mean change from baseline (ESI‐55 scale): Betts 2000.

QOL composite score	Period	PCB:number	PCB:mean change	LEV2g/d:number	LEV2g/d:mean change	LEV4g/d:number	LEV4g/d:mean change
Mental Health	Baseline	35	not applicable	40	not applicable	37	not applicable
Mental Health	Overall Double‐Blind	28	‐1.7 (worsened)	30	1.7 (improved)	28	3.5 (improved)
Physical Health	Baseline	29	not applicable	37	not applicable	34	not applicable
Physical Health	Overall Double‐Blind	28	3.6 (improved)	30	0.8 (improved)	26	2.3 (improved)
Role Functioning	Baseline	33	not applicable	38	not applicable	35	not applicable
Role Functioning	Overall Double‐Blind	28	‐0.5 (worsened)	31	0.4 (improved)	27	2.3 (improved)