11. Behavioral and emotional functioning assessment as least square mean change from baseline (CBCL and CHQ‐PF50): Levisohn 2009 & Loge 2010 (children).

Test	Subscale	n	Placebo (n=27)	n	Lev 60mg/kg/day (n=46)
CBCL competence scores	Activities	22	WORSENED*	41	Worsened
	Social	22	Worsened	41	Worsened
	School	19	Improved	35	Improved
	Total Competence	19	Worsened	34	Worsened
CBCL problem scores	Anxious/Depressed	22	Improved	43	Improved
	Withdrawn/Depressed		Improved		Worsened
	Somatic Complaints		Improved		Improved
	Social Problems		Improved		Worsened
	Thought Problems		Improved		Worsened
	Attention Problems		Improved		Improved
	Rule‐Breaking Behavior		Improved		Worsened
	Aggressive Behavior		IMPROVED*		WORSENED*
	Internalising Syndromesa		Improved		Improved
	Externalising Syndromesb		IMPROVED*		WORSENED*
	Total Problems		IMPROVED*		WORSENED*
CHQ‐PF50	Role/Social–Emotional/Behavioral	27	Worsened	45	Improved
	Behavior	27	Worsened	45	Worsened
	Mental Health	27	Improved	45	Improved
	Psychosocial Summary	26	Improved	44	Improved
Note: ( * ) p‐value < 0.05
aInternalising Syndromes contain the Withdrawn/Depressed, Anxious/Depressed, and Somatic Complaints scores bExternalising Syndromes contain the Agressive Behaviour and Rule‐Breaking Behaviour scores Note: Results were for per protocol population