Table 5.
Comparison Between Survivors and Non-Survivors with IC
| Survivors (n=160) | Non-Survivors (n=76) | P value | Crude OR (95% CI) | Adjusted OR (95% CI) | |
|---|---|---|---|---|---|
| Baseline Characteristics | |||||
| Age, years, mean±SD | 70.3±7.3 | 70.9±10.8 | 0.53 | 1.01(0.96–1.05) | |
| Male:Female | 105:55 | 49:27 | 0.86 | ||
| BMI, kg/m2, mean±SD | 21.5±3.3 | 21.8±3.9 | 0.56 | ||
| Tobacco use, n (%) | 44 (27.5) | 12 (15.8) | 0.05 | ||
| Charlson score, mean±SD | 5.0±2.1 | 5.4±2.4 | 0.72 | ||
| Polypharmacy, n (%) | 30 (18.8) | 26 (34.2) | 0.01* | 2.25 (1.21–4.18)* | |
| Comorbidities | |||||
| Hypertension, n (%) | 56 (35.0) | 34 (44.7) | 0.15 | ||
| Hematological or solid organ malignancy, n (%) | 56 (35.0) | 35 (46.1) | 0.10 | 1.50 (0.86–2.62) | |
| DM, n (%) | 41 (25.6) | 18 (23.7) | 0.75 | ||
| CKD, n (%) | 28 (17.5) | 12 (15.8) | 0.74 | ||
| CTD, n (%) | 13 (8.1) | 1 (1.3) | 0.04* | 0.15 (0.02–1.18) | |
| CAD, n (%) | 20 (12.5) | 11 (14.5) | 0.67 | ||
| COPD, n (%) | 14 (8.8) | 5 (6.6) | 0.57 | ||
| Solid organ transplantation, n (%) | 1 (0.6) | 4 (5.3) | 0.02* | 8.83 (0.97–80.44) | |
| Acute stroke, n (%) | 4 (2.5) | 3 (3.9) | 0.54 | ||
| Associated Factors | |||||
| Prolonged hospitalization, n (%) | 27 (16.9) | 20 (26.3) | 0.09 | 1.76 (0.91–3.39) | |
| Recent operation, n (%) | 68 (42.5) | 41 (53.9) | 0.10 | 1.59 (0.92–2.75) | |
| ICU admission, n (%) | 59 (36.9) | 62 (81.6) | <0.001* | 7.58 (3.91–14.71)* | 7.58 (3.91–14.71)* |
| Broad-spectrum antibiotics, n (%) | 113 (70.6) | 68 (89.5) | 0.001* | 3.54 (1.58–7.93)* | |
| CVC, n (%) | 65 (40.6) | 52 (68.4) | <0.001* | 3.17 (1.78–5.64)* | |
| Indwelling urinary catheter, n (%) | 74 (46.3) | 52 (68.4) | 0.001* | 2.52 (1.42–4.47)* | |
| TPN, n (%) | 5 (3.1) | 4 (5.3) | 0.42 | ||
| Prolonged use of GC, n (%) | 6 (3.8) | 3 (3.9) | 0.94 | ||
| Immunosuppressive therapy, n (%) | 12 (7.5) | 8 (10.5) | 0.44 | ||
| Disseminated fungal infection, n (%) | 39 (24.4) | 35 (46.1) | 0.001* | 2.65 (1.49–4.72)* | |
| Laboratory Data | |||||
| Neutropenia, n (%) | 5 (3.1) | 3 (3.9) | 0.74 | ||
| Grade I, n (%) | 1 (0.6) | 0 (0) | |||
| Grade II, n (%) | 1 (0.6) | 1 (1.3) | |||
| Grade III, n (%) | 2 (1.3) | 1 (1.3) | |||
| Grade, IV, n (%) | 1 (0.6) | 1 (1.3) | |||
| Lymphopenia, n (%) | 61 (38.1) | 37 (48.7) | 0.12 | ||
| Anemia, n (%) | 82 (51.3) | 44 (57.9) | 0.34 | ||
| Mild, n (%) | 37 (23.1) | 21 (27.6) | |||
| Moderate, n (%) | 41 (25.6) | 19 (25.0) | |||
| Severe, n (%) | 4 (2.5) | 3 (3.9) | |||
| Very severe, n (%) | 0 (0) | 1 (1.3) | |||
| Hypoalbuminemia, n (%) | 89 (55.6) | 51 (67.1) | 0.09 | ||
| Initial adequate treatment, n (%) | 79 (49.4) | 46 (60.5) | 0.11 |
Note: *P<0.05.
Abbreviations: BMI, body mass index; CAD, coronary artery disease; CI, confidential interval; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; CTD, connective tissue disease; CVC, central venous catheter; DM, diabetes mellitus; GC, glucocorticoid; IC, invasive candidiasis; ICU, intensive care unit; OR, odds ratio; SD, standard deviation; TPN, total parenteral nutrition.