Figure 3.

MIIP-knockdown promoted tumor bone metastatic lesion in vivo. A. Representative BLIs signal of bone metastasis of a mouse inoculated with luciferase-expressing, PC3-Scramble or PC3-MIIP shRNA cells via intra-tibial injection. B. Quantification of the BLI signaling in the Scramble (n=7) and MIIP-shRNA (n=7) groups at 21 and 35 day respectively. *P<0.05. C. Representative radiographic images of bone metastases in the indicated mice at 42 day (arrows indicate osteolytic lesions). D. The quantification of radiographic score in tumor-bearing mice inoculated via tibia with Scramble or MIIP shRNA cells. *P<0.05.