Figure 6.

The expression of MIIP is downregulated in prostate cancer tissues and positively correlated with the expression of KLF17. A. MIIP, KLF17 and E-cadherin protein levels were detected by Western blot in 7 paired prostate cancer samples from human patients; tumor and adjacent normal tissue. N, normal tissue; T, tumor tissue. B. miR-181a/b-5p expression was enhanced in clinic prostate cancer samples (n = 11) compared with paired adjacent normal tissues; two-tailed Student’s t-test. C, D. MIIP and KLF17 expression was evaluated by immunohistochemical staining on two independent TMAs composed of normal and adjacent normal prostate tissues, and PCa tissues of Gleason score 3, 4 and 5 grades. D. The correlation between MIIP and KLF17 expression level in normal, adjacent normal prostate tissues, and PCa tissues, Pearson R = 0.7154. All data are shown as mean ± SD.