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The B3 and C12 PARP inhibitor-resistant TNBC cells exhibit higher levels of phospho-c-MET expression compared with SUM149 PARPi-sensitive parental TNBC cells. The indicated cells were treated with vehicle control (con), olaparib (ola) at a concentration of 0.5 µM or 1.0 µM, or talazoparib (Tala) at a concentration of 25 nM for 24 hr prior to preparation of whole cell lysates. Immunoblotting was used to determine relative levels of phospho-c-MET, total c-MET and lamin B expression.
