Table 4.

Univariate and multivariate Cox regression analysis of P2X7R and GLUT-1 expression for correlation with disease-free survival

Parameters	Univariate		Multivariate
	HR (95% CI)	P value	HR (95% CI)	P value
Sex (male/female)	1.06 (0.66-1.72)	0.784	0.71 (0.40-1.26)	0.245
Age (19-44/45-54/≥55)	1.58 (0.67-3.73)	0.291	1.24 (0.78-1.97)	0.361
Tumor site (right/left)	0.40 (0.24-0.64)	<0.001	0.75 (0.41-1.38)	0.362
Grade (well/modarete/poor)	2.79 (1.26-6.19)	0.011	1.15 (0.73-1.81)	0.529
V.I. (absent/present)	1.52 (0.86-2.66)	0.143	0.77 (0.41-1.44)	0.442
TILs (low/high)	0.18 (0.10-0.32)	<0.001	0.15 (0.08-0.27)	<0.001
pT (T1/T2/T3)	6.45 (2.31-17.97)	0.001	0.91 (0.58-1.43)	0.707
pN (absent/1-3/≥4)	3.96 (2.14-7.31)	<0.001	0.96 (0.67-1.36)	0.830
TNM stage (I/II/III/IV)	3.73 (1.14-12.13)	0.029	2.56 (1.52-3.20)	<0.001
P2X7R expression (low/high)	9.98 (5.89-17.82)	<0.001	3.85 (1.93-7.65)	<0.001
GLUT-1 expression (low/high)	3.89 (2.36-6.42)	<0.001	1.52 (0.96-2.01)	0.043

HR: hazard ratio; CI: confidence interval; V.I.: vascular invasion.