Table 3.
Univariate logistic regression model analysis of factors predicting cardiotoxicity
| Items | Univariate logistic regression | |||
|---|---|---|---|---|
|
| ||||
| P value | OR | 95% CI | ||
|
| ||||
| Lower | Higher | |||
| HER2 codon 655 (GG=2, AG=1, AA=0) | 0.008 | 3.117 | 1.337 | 7.266 |
| Age | 0.155 | 1.047 | 0.983 | 1.115 |
| BMI | 0.013 | 1.321 | 1.059 | 1.647 |
| Smoking (yes vs. no) | 0.020 | 3.437 | 1.217 | 9.710 |
| Hypertension (yes vs. no) | 0.021 | 3.239 | 1.193 | 8.795 |
| Diabetes mellitus (yes vs. no) | 0.565 | 1.722 | 0.271 | 10.955 |
| Dyslipidemia (yes vs. no) | 0.146 | 2.118 | 0.770 | 5.820 |
| Hyperuricemia (yes vs. no) | 0.029 | 3.294 | 1.128 | 9.619 |
| Chronic kidney disease (yes vs. no) | 0.135 | 4.109 | 0.645 | 26.178 |
| ECOG score (1 vs. 0) | 0.248 | 1.765 | 0.673 | 4.630 |
| cTnI (M0) | <0.001 | 1.030 | 1.015 | 1.044 |
| NT-proBNP (M0) | 0.010 | 1.015 | 1.004 | 1.026 |
Factors predicting cardiotoxicity were determined by univariate logistic regression analysis. P value <0.05 was considered significant. HER2: human epidermal growth factor receptor-2; BMI: body mass index; ECOG: Eastern Cooperative Oncology Group; cTnI: cardiac troponin I; NT-proBNP: N terminal pro B type natriuretic peptide.